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Test Code B2MIC Beta-2-Microglobulin, Serum

Reporting Name

Beta-2-Microglobulin, S

Useful For

Prognosis assessment of multiple myeloma

 

Evaluation of renal tubular disorders

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL


Specimen Minimum Volume

0.5 mL

Testing Algorithm

See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values

1.21-2.70 mcg/mL

Day(s) and Time(s) Performed

Monday through Friday; 3 p.m.

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82232

LOINC Code Information

Test ID Test Order Name Order LOINC Value
B2M Beta-2-Microglobulin, S 1952-1

 

Result ID Test Result Name Result LOINC Value
B2M Beta-2-Microglobulin, S 1952-1

Clinical Reference

1. Bataille R, Magub M, Grenier J, et al: Serum beta-2-microglobulin in multiple myeloma: Relation to presenting features and clinical status. Eur J Cancer Clin Oncol 1982;18:59-66

2. Garewal H, Durie BG, Kyle RA, et al: Serum beta-2-microglobulin in the initial staging and subsequent monitoring of monoclonal plasma cell disorders. J Clin Oncol 1984;2:51-57

3. Norfolk D, Child JA, Cooper EH, et al: Serum beta-2-microglobulin in myelomatosis: potential value in stratification and monitoring. Br J Cancer 1980;42:510-550

4. Dolan MJ, Lucey DR, Hendrix CW, et al: Early markers of HIV infection and subclinical disease progression. Vaccine 1993;11:548-551

5. Karlsson FA, Wibell L, Evrin PE: Beta-2-microglobulin in clinical medicine. Scand J Clin Lab Invest 1986;154:27-37

6. Greipp PR, Katzmann JA, O'Fallon WM, Kyle RA: Value of beta-2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma. Blood 1988;72:219-223

Method Description

Concentrations of beta-2-microglobulin are determined by nephelometry.(Instruction manual: Siemens Nephelometer II Operations. Siemens, Inc., Newark, DE)

Analytic Time

Same day/1 day

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Nephelometry

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Renal Diagnostics Test Request (T830)

Secondary ID

9234