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HelpTest Code CA125 Cancer Antigen 125
Additional Codes
Epic: LAB155
Specimen Required
Collection Conatiner/Tube: Serum SST
Submission Container/Tube: Plastic vial
Specimen Volume: 3.0 mL
Collection Instructions: Centrifuge and separate
cells after clot formation and within 4 hours of collection.
Specimen Minimum Volume
1.0 mL
Specimen Stability
Room Temperature: Unacceptable.
Refrigerated on gel: 24 hours
Refrigerated off gel: 7 days
Frozen: >7 days
Reference Range
<35.0 U/mL
Rejection Due To
Specimens stored on gel >24 hours, gross hemolysis
Report Available
Same day
Clinical Significance
CA 125 is a glycoprotein antigen present in tissues derived from ovarian, fallopian, peritoneal, colon, kidney, stomach, and other coelomic tissue. Increased levels are seen in patients with ovarian and intraperitoneal malignancy; the percentage of positive cases increasing with the cancer stage. CA 125 is also used to assess the effectiveness of ovarian/intraperitoneal cancer treatments and to predict recurrence and prognosis. Elevated levels of CA 125 may be seen in nonmalignant conditions, first trimester pregnancy, ovarian cysts, pelvic inflammatory disease, and during the menstrual cycle.
Method Name
Chemiluminescent Micro-particle Immunoassay (CMIA)
Limitations
Patients with Heterophile antibodies (HAMA) may exhibit falsely
elevated or falsely depressed results.
CA 125 results should not be used interchangeably with other
manufacturers’ methods for CA 125 determinations.
Consistent tube type should be used to collect serial
specimens.
CA 125 levels are not useful in screening the general population
for cancer.
CA 125 levels should not be used alone as absolute evidence of the
presence or absence of malignant disease. Clinical evaluation
and other diagnostic procedures are needed.
LOINC
10334-1
Day(s) Performed
Daily