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HelpTest Code CASF IgG/Albumin Ratio, Spinal Fluid
Reporting Name
IgG/Albumin Ratio, CSFUseful For
Assessment of cerebrospinal fluid (CSF) IgG/albumin ratio in the absence of a paired CSF and serum specimen
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
CSFAdvisory Information
The cerebrospinal fluid (CSF) index in which the CSF IgG/albumin ratio is compared to the serum IgG/albumin ratio aids in the diagnosis of individuals with multiple sclerosis. See SFIN / Cerebrospinal Fluid (CSF) IgG Index, Serum and Spinal Fluid.
Specimen Required
Collection Container/Tube: Sterile vial
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Ambient | 14 days | ||
| Frozen | 14 days |
Reference Values
CSF IgG: 0.0-8.1 mg/dL
CSF albumin: 0.0-27.0 mg/dL
CSF IgG/albumin: 0.00-0.21
Day(s) and Time(s) Performed
Monday through Friday; 2 p.m.
Test Classification
This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82042
82784
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CASF | IgG/Albumin Ratio, CSF | 2470-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| IGG_C | IgG, CSF | 2464-6 |
| ALB_C | Albumin, CSF | 1746-7 |
| AIGAC | IgG/Albumin, CSF | 2470-3 |
Clinical Reference
1. Tourtellotte WW, Walsh MJ, Baumhefner RW, et al: The current status of multiple sclerosis intra-blood-brain-barrier IgG synthesis. Ann NY Acad Sci 1984;436:52-67
2. Bloomer LC, Bray PF: Relative value of three laboratory methods in the diagnosis of multiple sclerosis. Clin Chem 1981;27(12):2011-2013
3. Hische EA, van der Helm HJ: Rate of synthesis of IgG within the blood-brain barrier and the IgG index compared in the diagnosis of multiple sclerosis. Clin Chem 1987;33(1):113-114
4. Swanson JW: Multiple Sclerosis: Update in diagnosis and review of prognastic factors. Mayo Clin Proc 1989;64:577-586
5. Markowitz H, Kokmen E: Neurologic diseases and the cerebrospinal fluid immunoglobulin profile. Mayo Clin Proc 1983;58:273-274
Method Description
The cerebrospinal fluid (CSF) and albumin are determined by immunonephelometry on a Siemens Nephelometer II. CSF IgG and albumin, and CSF IgG/albumin ratios are reported.(Instruction manual: Siemens Nephelometer II Operations. Siemens, Inc., Newark, DE. May 2005)
Analytic Time
Same day/1 dayReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Nephelometry