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Test Code CATN Calcitonin, Serum

Reporting Name

Calcitonin, S

Useful For

Aids in the diagnosis and follow-up of medullary thyroid carcinoma

 

Aids in the evaluation of multiple endocrine neoplasia type II and familial medullary thyroid carcinoma

 

This test is not useful for evaluating calcium metabolic diseases.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Patient Preparation: For the 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.8 mL

Collection Instructions:

1. After collection, immediately place specimen on ice.

2. Refrigerate specimen during centrifugation and immediately transfer serum to a plastic vial.


Specimen Minimum Volume

0.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 90 days
  Refrigerated  24 hours
  Ambient  4 hours

Reference Values

Pediatric

1 month: ≤34 pg/mL

2 months: ≤31 pg/mL

3 months: ≤28 pg/mL

4 months: ≤26 pg/mL

5 months: ≤24 pg/mL

6 months: ≤22 pg/mL

7 months: ≤20 pg/mL

8 months: ≤19.0 pg/mL

9 months: ≤17.0 pg/mL

10 months: ≤16.0 pg/mL

11 months: ≤15.0 pg/mL

12-14 months: ≤14.0 pg/mL

15-17 months: ≤12.0 pg/mL

18-20 months: ≤10.0 pg/mL

21-23 months: ≤9.0 pg/mL

2 years: ≤8.0 pg/mL

3-9 years: ≤7.0 pg/mL

10-15 years: ≤6.0 pg/mL

16 years: ≤5.0 pg/mL

 

Adults

17 years and older:

Males: ≤14.3 pg/mL

Females: ≤7.6 pg/mL

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-12 a.m.

Saturday; 6 a.m.-6 p.m.

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82308

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CATN Calcitonin, S 1992-7

 

Result ID Test Result Name Result LOINC Value
CATN Calcitonin, S 1992-7

Clinical Reference

1. Wells SA Jr, Asa SL, Dralle H, et al: Medullary Thyroid Carcinoma: management guidelines of the American Thyroid Association. American Thyroid Association Guidelines Task Force 2015 Jun;25(6):567-610

2. Griebeler ML, Gharib H, Thompson GB: Medullary thyroid carcinoma. Endocr Pract 2013 Jul-Aug;19(4):703-11

3. Richards ML: Familial syndromes associated with thyroid cancer in the era of personalized medicine. Thyroid 2010 Jul;20(7):707-13

Method Description

Testing is performed on the Roche cobas. The Roche Human Calcitonin (hCT) assay is a sandwich electrochemiluminescence immunoassay that employs a biotinylated monoclonal hCT-specific antibody and a monoclonal hCT-specific antibody. Calcitonin in the specimen reacts with both the biotinylated monoclonal hCT-specific antibody and the monoclonal hCT-specific antibody labeled with a ruthenium complex, forming a sandwich complex. Streptavidin-coated microparticles are added and the mixture is aspirated into the measuring cell where the microparticles are magnetically captured onto the surface of the electrode. Unbound substances are then removed with ProCell. Application of voltage to the electrode induces the chemiluminescent emission, which is then measured.(Package insert: Elecsys Calcitonin, Roche Diagnostics, Indianapolis, IN,, V 1.0, 05/2017)

Analytic Time

Same day/1 day

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Method Name

Electrochemiluminescence Immunoassay

Secondary ID

9160