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Test Code CRPHS C-Reactive Protein, High Sensitivity

Additional Codes

Epic: LAB2233

Specimen Required

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gel

Acceptable: Green top (Lithium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and separate cells after clot formation and within 4 hours of collection.  

Additional Information: Specimens from patients receiving anticoagulant or thrombolytic therapy may take longer to complete their clotting processes. Fibrin clots may form in these sera and the clots could cause erroneous test results.

Specimen Minimum Volume

0.25  mL

Specimen Stability

Room temperature: 15 days

Refrigerated: 2 months

Frozen: 3 years

Reference Range

≤ 0.5 mg/dL

Rejection Due To

Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, QNS, exceeds specimen stability requirements.

Report Available

Same day

Clinical Significance

C-reactive protein is an acute phase protein whose concentration rises non-specifically in response to inflammation.  CRP is seen to increase as a result of the inflammatory process, most notably in response to pneumococcal (bacterial) infection, histolytic disease, and a variety of other disease states. CRP is used as a marker or general diagnostic indicator of infections and inflammation, in addition to serving as a monitor of patient response to pharmacological therapy and surgery.

Method Name



CRP is not a substitute for traditional cardiovascular risk factors.
Acute coronary syndrome management should not depend on CRP measurements.
Patients with persistently unexplained CRP levels above 1.0 mg/dL should be evaluated for noncardiovascular etiologies.



Day(s) Performed