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Test Code FISHI FISH, AML, CBFB/MYH11, Inversion 16

Specimen Required

5 mL whole blood or 3 mL bone marrow

Specimen Minimum Volume

1 mL

Specimen Stability

Room temperature: See instructions Refrigerated: See instructins Frozen: See instructions

Rejection Due To

Received frozen

Day(s) and Time(s) Performed

Set up: Daily; Report available: 5 days

Method Name

Fluorescence in situ Hybridization (FISH)

Collection Container / Tube

Preferred: Sodium Heparin (green top) tube
Other Acceptable Container: Sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube

Transport / Storage Conditions

Room temperature

Special Instructions

Clinical history and reason for referral are required with test order. Prior therapy/transplant information should be submitted with test order.

Specimen requirements: 3-5 mL whole blood or 1-3 mL bone marrow collected in a sodium heparin tube.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Note: If results are not possible, the test order may be canceled and replaced by a "Cytogenetics Communication".

Reference Values

See Laboratory Report

CPT Codes

88271 (x2), 88275

Clinical Reference

This test is performed to detect the CBFB rearrangements such as inversion (16) and translocation t(16;16), by FISH (fluorescence in situ hybridization). This assay is useful for diagnosis of acute myeloid leukemia (AML) with inv(16) or t(16;16); CBFB-MYH11.