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Test Code FISHP FISH, AML M3,PML/RARA,Translocation 15,17

Specimen Required

5 mL whole blood or 3 mL bone marrow

Specimen Minimum Volume

1 mL

Specimen Stability

Room temperature: See instructions Refrigerated: See instructins Frozen: See instructions

Method Name

Fluorescence in situ Hybridization (FISH)


If results are not possible from the submitted specimen, the test order will be canceled and replaced with a Cytogenetics Communication.

Collection Container / Tube

Preferred: sodium heparin (green top) tube
Other Acceptable Container: Sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube

Transport / Storage Conditions

Room temperature

Special Instructions

Clinical history and reason for referral are required with test order. Prior therapy/transplant history should be submitted with test order.
Specimen Requirements: Bone marrow 1-3 mL, or whole blood 3-5 mL collected in a sodium heparin tube.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Reference Values

See Laboratory Report

Day(s) Performed

Set up: Daily; Report available: 5 days

CPT Codes

88275, 88271 (x2)

Clinical Reference

This test is performed to detect the PML-RARA fusion, t(15;17), by FISH (fluorescence in situ hybridization). This assay is useful for diagnosis and monitoring of acute promyelocytic leukemia.