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Test Code GAL3M Galectin-3, Serum

Additional Codes

Epic: LAB14853

Mayo: GAL3

Reporting Name

Galectin-3, S

Useful For

Aiding in the prognosis for patients diagnosed with heart failure

 

Risk-stratification of heart failure patients

 

An early indication of treatment failure and as a therapeutic target

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red

Specimen Required


Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen (preferred) 365 days
  Refrigerated  24 hours

Reference Values

<24 months: not established

2-17 years: ≤25.0 ng/mL

≥18 years: ≤22.1 ng/mL

Day(s) Performed

Monday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82777-Galectin-3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GAL3 Galectin-3, S 62419-7

 

Result ID Test Result Name Result LOINC Value
86202 Galectin-3, S 62419-7

Clinical Reference

1. Van der Velde AR, Meijers WC, Van den Heuvel ER, et al: Determinants of temporal changes in galectin-3 level in the general population: Data of PREVEND. Int J Cardiol 2016;222:385-390. doi: 10.1016/j.ijcard.2016.07.241

2. Mueller T, Gegenhuber A, Leitner I, et al: Diagnostic and prognostic accuracy of galectin-3 and soluble ST2 for acute heart failure. Clin Chim Acta 2016;463:158-164. doi: 10.1016/j.cca.2016.10.034

3. Sudharshan S, Novak E, Hock K, et al: Use of biomarkers to predict readmission for congestive heart failure. Am J Cardiol 2017;119:445-451. doi: 10.1016/j.amjcard.2016.10.022

4. Meijers WC, van der Velde AR, Muller Kobold AC, et al: Variability of biomarkers in patients with chronic heart failure and healthy controls. Eur J Heart Fail 2017;19:357-365. doi: 10.1002/ejhf.669

5. Meeusen JW, Johnson JN, Gray A, et al: Soluble ST2 and galectin-3 in pediatric patients without heart failure. Clin Biochem 2015;Dec;48(18):1337-1340. doi: 10.1016/j.clinbiochem.2015.08.007

Method Description

The galectin-3 assay is a diagnostic, quantitative 2-site manual enzyme-linked immunosorbent assay (ELISA) validated for use in human sera. The capture monoclonal antibody (rat IgG2a) is immobilized on 96-well plates, while the detection antibody utilizes a mouse monoclonal antibody that targets the human galectin-3 protein and is conjugated with horseradish peroxidase. This is an FDA 510K-cleared in vitro diagnostic device.(Package insert: BGM Galectin-3 Assay, BG Medicine, Inc. 05/2015)

Report Available

1 to 8 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Forms

If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.