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Test Code HAPT Haptoglobin

Additional Codes

Epic: LAB89

Specimen Required

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gel

Acceptable: Green top (Lithium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and separate cells after clot formation and within 4 hours of collection. 

Additional Information:

  1. Specimens from patients receiving anticoagulant or thrombolytic therapy may take longer to complete their clotting processes. Fibrin clots may form in these sera and the clots could cause erroneous test results.

Specimen Minimum Volume

0.25 mL

Specimen Stability

Room temperature: Not defined

Refrigerated: 1 weeks

Frozen: 2 weeks

Reference Range


0 - 1 year: 0 - 300 mg/dL

1 - 12 year: 3 - 270 mg/dL

12 - 60 years: 40- 258 mg/dL

>60 years: 40 - 268 mg/dL



0 - 1 year: 0 - 235 mg/dL

1 - 12 year: 11 - 220 mg/dL

12 - 60 years: 35 - 250 mg/dL

>60 years: 63 - 273 mg/dL

Rejection Due To

Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, QNS, exceeds specimen stability requirements.

Report Available

Same day

Clinical Significance

Haptoglobin is a protein synthesized in the liver that binds with the globin α‑chains of hemoglobin A, F, S, or C. The haptoglobin-hemoglobin complex is rapidly removed from circulation by the reticuloendothelial system to prevent/minimize hemoglobin loss and to conserve iron.
Indications for haptoglobin quantitation include: anemia or other indicators of possible hemolysis; pregnancy-induced hypertension; transfusion reactions. Decreased levels of haptoglobin are most frequently associated with conditions of increased intravascular hemolysis or hemoglobin turnover, such as hemolytic anemias, intravascular hemolytic transfusion reactions, and malaria. Elevated levels of haptoglobin are most frequently associated with acute phase reactions involving tissue infection, surgery, trauma, or necrosis). Corticosteroid therapy and biliary obstruction can also cause elevation.

Method Name



Samples containing paraproteins (abnormal monoclonal antibodies) may interfere with test results. Samples with elevated total protein concentrations or samples from patients with suspected paraproteinemia can be screened using other methods such as protein electrophoresis.



Day(s) Performed