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Test Code HBA1G Hemoglobin A1c plus AEG

Additional Codes

Epic: LAB90

Specimen Required

Patient Preparation:
Specimen Type: Whole Blood EDTA
Collection Container/Tube: Lavedner top (EDTA)
Specimen Volume: 3.0 mL
Collection Instructions: 

  1. Be sure to fill tube completely.
  2. Send specimen in original tube.  Do not aliquot.

 

Specimen Minimum Volume

1.0 mL

Specimen Stability

Room temperature: 8 hours

Refrigerated: 7 days

Frozen: Unacceptable

Reference Range

4.6 - 5.9 %

 

HbA1c values above 6.5 %HbA1c (48 mmol/mol) are an indication of hyperglycemia during the preceding 2 to 3 months or longer. According to the recommendations of the ADA, HbA1c values above 6.5 %HbA1c (48 mmol/mol) are suitable for the diagnosis of diabetes mellitus. Patients with HbA1c values in the range of 5.7 - 6.4 %HbA1c(39 - 46 mmol/mol) may be at a risk of developing diabetes.

Rejection Due To

Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, clotted, QNS, exceeds specimen/stability requirements.

Report Available

Same day

Clinical Significance

HbA1c is formed by the reaction of glucose with the N-terminal amino group of the hemoglobin beta chain. The Diabetes Control and Complications Trial (DCCT) Research Group previously reported a relationship between percent HbA1c and mean blood glucose levels during the preceding 2‑3 months. The DCCT study also demonstrated that long-term control of diabetes can prevent complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy. Measurement of percent HbA1c is the method of choice for monitoring therapy of diabetic patients.

Method Name

Enzymatic 

Includes

Hemoglobin A1C

Average Estimated Glucose

Limitations

The Hemoglobin A1c assay is susceptible to interference effects from conjugated bilirubin at > 15.0 mg/dL (180 μmol/L),unconjugated bilirubin at > 10.0 mg/dL (171 μmol/L) and Triglycerides >3000 mg/dL.
Glycated HbF is not detected by the assay as it does not contain the β-chain that characterizes HbA1c. However, HbF is measured in the total Hb assay and as a consequence, specimens containing high amounts of HbF (> 5%) may result in lower than expected mmol/mol HbA1c values (IFCC) and %HbA1c values (NGSP).
If patient has a known homozygous or double heterozygous hemoglobinopathy, HBA1C results may be inaccurate. Fructosamine is the method of choice for those patients.

Aliases

A1c

Glycohemoglobin

HBA1C

Hemoglobin A1c

Day(s) Performed

Daily

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