Test Code HBA1G Hemoglobin A1c plus AEG
Additional Codes
Epic: LAB90
Specimen Required
Patient Preparation:
Specimen Type: Whole Blood EDTA
Collection Container/Tube: Lavedner top
(EDTA)
Specimen Volume: 3.0 mL
Collection Instructions:
- Be sure to fill tube completely.
- Send specimen in original tube. Do not aliquot.
Specimen Minimum Volume
1.0 mL
Specimen Stability
Room temperature: 8 hours
Refrigerated: 7 days
Frozen: Unacceptable
Reference Range
4.6 - 5.9 %
HbA1c values above 6.5 %HbA1c (48 mmol/mol) are an indication of hyperglycemia during the preceding 2 to 3 months or longer. According to the recommendations of the ADA, HbA1c values above 6.5 %HbA1c (48 mmol/mol) are suitable for the diagnosis of diabetes mellitus. Patients with HbA1c values in the range of 5.7 - 6.4 %HbA1c(39 - 46 mmol/mol) may be at a risk of developing diabetes.
Rejection Due To
Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, clotted, QNS, exceeds specimen/stability requirements.
Report Available
Same day
Clinical Significance
HbA1c is formed by the reaction of glucose with the N-terminal amino group of the hemoglobin beta chain. The Diabetes Control and Complications Trial (DCCT) Research Group previously reported a relationship between percent HbA1c and mean blood glucose levels during the preceding 2‑3 months. The DCCT study also demonstrated that long-term control of diabetes can prevent complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy. Measurement of percent HbA1c is the method of choice for monitoring therapy of diabetic patients.
Method Name
Enzymatic
Includes
Hemoglobin A1C
Average Estimated Glucose
Limitations
The Hemoglobin A1c assay is susceptible to interference effects
from conjugated bilirubin at > 15.0 mg/dL (180
μmol/L),unconjugated bilirubin at > 10.0 mg/dL (171
μmol/L) and Triglycerides >3000 mg/dL.
Glycated HbF is not detected by the assay as it does not contain
the β-chain that characterizes HbA1c. However, HbF is measured
in the total Hb assay and as a consequence, specimens containing
high amounts of HbF (> 5%) may result in lower than expected
mmol/mol HbA1c values (IFCC) and %HbA1c values (NGSP).
If patient has a known homozygous or double heterozygous
hemoglobinopathy, HBA1C results may be inaccurate. Fructosamine is
the method of choice for those patients.
Aliases
A1c
Glycohemoglobin
HBA1C
Hemoglobin A1c
Day(s) Performed
Daily