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Test Code IBDDP Inflammatory Bowel Disease Differentiation Panel

Additional Codes

Epic: LAB12264

Testing Algorithm

If ANCA Screen is positive, then C-ANCA Titer and/or P-ANCA Titer, and/or atypical P-ANCA Titer will be performed at an additional charge (CPT code(s): 86021 for each titer performed).

Specimen Required

Patient Preparation: 

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Specimen Minimum Volume

1.4 mL

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Reference Range

ANCA Screen Negative
  P-ANCA Titer <1:20
  C-ANCA Titer <1:20
  Atypical P-ANCA Titer <1:20

Myeloperoxidase Antibody

<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Proteinase-3 Antibody

<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Saccharomyces cerevisiae Ab (IgG)

≤20.0 U Negative
20.1-29.9 U Equivocal
≥30.0 U Positive

Saccharomyces cerevisiae Ab (IgA)

≤20.0 U Negative
20.1-24.9 U Equivocal
≥25.0 U Positive

Rejection Due To

Gross hemolysis • Lipemic specimens

Report Available

3-5 days

Clinical Significance

These tests are intended to aid in the diagnosis of Crohn's Disease. A positive P-ANCA aids in the differentiation of patients with ulcerative colitis.

Method Name

Immunoassay (IA)

Performing Laboratory

Quest Diagnostics

Chantilly, VA


8796 Myeloperoxidase Antibody
10294 Saccharomyces cerevisiae Antibody (ASCA) (IgG)
10295 Saccharomyces cerevisiae Antibody (ASCA) (IgA)
34151 Proteinase-3 Antibody
70171 ANCA Screen with Reflex to ANCA Titer


IBD Panel

Day(s) Performed

Monday - Saturday, P.M.


86021 (x3), 86671 (x2)