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Test Code IL28B AccuType(TM) IL28B

Specimen Required

5 mL whole blood

Specimen Minimum Volume

2 mL

Specimen Stability

Whole blood
 Room temperature: 8 days
Refrigerated: 8 days
Frozen: Unacceptable

Buccal swab
 Room temperature: 14 days
Refrigerated: Unacceptable
Frozen: Unacceptable

Rejection Due To

Received frozen • Buccal swab received refrigerated • Incorrect collection device • Liquid has leaked from container/no liquid present

Report Available

Set up: Daily night; Report available: 3 days

Method Name

Real-Time Polymerase Chain Reaction

Collection Container / Tube

Preferred: EDTA (lavendar-top) tube.
Other Acceptable Container: ACD solution A or B (yellow-top) tube Buccal swab collected in: DNA Genotek Oracollect Kit, or Celera DNA Collection Kit (follow collection kit instructions)

Transport / Storage Conditions

Room temperature

Special Instructions

Do not freeze whole blood.

Buccal Swab: Use only Celera/Copan DNA Collection Kit (Celera part # is 5002737) or DNA Genotek OraCollect Kit (OC-100). Follow collection kit instructions.

Reference Values

See Laboratory Report

Day(s) Performed

Set up: Daily night; Report available: 3 days

CPT Codes

81283
This test is for non-New York patient testing. For New York testing, please see Test Code 90252.

Clinical Reference

The C polymorphism in rs12979860 is strongly associated with a two fold greater sustained virological response in European, African American, and Hispanic populations. Knowledge of the host genotype of patients infected with HCV will aid in the clinical decision to initiate treatment with PegIFN and RBV (a 48 week course of interferon and ribavirin which has limited efficacy and is often poorly tolerated due to side effects that prevent patients from finishing treatment).

Patient Preparation

Do not eat immediately prior to sample collection. If patient has eaten recently, rinse mouth with plain water.