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Test Code INHA Inhibin A, Tumor Marker, Serum

Reporting Name

Inhibin A, Tumor Marker, S

Useful For

Aiding in the diagnosis of patients with granulosa cell tumors of the ovary when used in combination with inhibin B

 

Monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to secrete inhibin A

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Advisory Information


For the initial evaluation of patients suspected of having a granulosa cell tumor of the ovary, order INHAB / Inhibin A and B, Tumor Marker, Serum. If the results of the profile show that either inhibin A or B are elevated, consider monitoring the patient with the individual tests, INHA / Inhibin A, Tumor Marker, Serum or INHB / Inhibin B, Serum.



Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.6 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  90 days

Reference Values

Males: <2.0 pg/mL

Females

<11 years: <4.7 pg/mL

11-17 years: <97.5 pg/mL

Premenopausal: <97.5 pg/mL

Postmenopausal: <2.1 pg/mL

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-9 p.m.

Saturday; 6 a.m.-1 p.m

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86336

LOINC Code Information

Test ID Test Order Name Order LOINC Value
INHA Inhibin A, Tumor Marker, S 23883-2

 

Result ID Test Result Name Result LOINC Value
INHA Inhibin A, Tumor Marker, S 23883-2

Clinical Reference

1. Mom CH, Engelen MJ, Willemse PH, et al: Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 2007 May;105(2):365-372

2. Robertson DM, Pruysers E, Jobling T: Inhibin as a diagnostic marker for ovarian cancer. Cancer Lett 2007;249:14-17

3. Jamieson S, Fuller PJ: Management of granulosa cell tumour of the ovary. Curr Opin Oncol 2008;20(5):560-564

4. Sturgeon C: Ch 31 Tumor Markers, In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Sixth edition. Edited by N Rafai, AR Horvath, CT Wittwer. Elsevier, 2018, pp 436-478

5. Yarbrough ML, Stout M, Gronowski AM: Ch 69 Pregnancy and Its Disorders. In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Sixth edition. Edited by N Rafai, AR Horvath, CT Wittwer. Elsevier, 2018, pp 1655-1696

6. Makanji Y, Zhu J, Mishra R, et al: Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev 2014;35(5):747–794. doi:10.1210/er.2014-1003

7. Walentowicz P, Krintus M, Sadlecki P, et al: Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients. PLoS One. 2014;9(3):e90575. doi:10.1371/journal.pone.0090575

Method Description

The instrument used is a Beckman Coulter Unicel DXI 800. The Access Inhibin A assay is a sequential 2-step immunoenzymatic ("sandwich'') assay. Sample is added to a reaction vessel and incubated with paramagnetic particles coupled with anti-inhibin A monoclonal antibody. Excess sample and reagents are removed and anti-inhibin A monoclonal antibody-alkaline phosphatase conjugate is then added to a reaction mixture. After incubation, unbound materials are washed away. Antibody-analyte complex is detected by addition of the chemiluminescent substrate Lumi-Phos* 530. The light production is directly proportional to the concentration of inhibin A in the sample.(Package insert: Beckman Coulter Inc, Fullerton, CA, 07/2019)

Analytic Time

Same day/1 day

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Method Name

Sequential 2-Step Immunoenzymatic Assay