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Test Code LEVET Levetiracetam, Serum

Additional Codes

Mayo test code: LEVE

Reporting Name

Levetiracetam, S

Useful For

Monitoring serum concentration of levetiracetam, particularly in patients with renal disease

 

Assessing compliance

 

Assessing potential toxicity

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. For sustained-release formulations ONLY, draw blood a minimum of 12 hours after last dose.

3. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

10.0-40.0 mcg/mL

Day(s) and Time(s) Performed

Monday through Friday; Continuously until 2 p.m.

Saturday; Continuously until 1 p.m.

Sunday; 11 a.m.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80177

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LEVE Levetiracetam, S 30471-7

 

Result ID Test Result Name Result LOINC Value
83140 Levetiracetam, S 30471-7

Clinical Reference

1. Patsalos PN, Berry DJ, Bourgeois BF, et al: Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring. ILAE Commission on Therapeutic Strategies. Epilepsia. 2008 Jul;49(7):1239-1276 2. Johannessen SI, Tomson T: Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Pharmacokinet. 2006;45(11):1061-1075 3. Hiemke C, Bergemann N, Clement HW, et al: Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: Update 2017. Pharmacopsychiatry. 2018 Jan;51(1-02):9-62

Method Description

The serum sample is diluted in acetonitrile containing internal standard. The protein precipitate is centrifuged and a portion of the supernatant is diluted with mobile phase for detection by a tandem mass spectrometer (MS/MS).(Unpublished Mayo method)

Analytic Time

Same day/1 day

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-General Request (T239)

-Therapeutics Test Request (T831)

Secondary ID

83140
Inova Laboratories Additional Information:

Keppra (Alias)