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HelpTest Code LIPA Lipoprotein (a), Serum
Reporting Name
Lipoprotein (a), SUseful For
Cardiovascular disease (CVD) risk refinement in patients with moderate or high risk based on conventional risk factors
This test is not recommended as a screening test in the healthy population.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Patient Preparation: Fasting-overnight (12-14 hours)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send refrigerated.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 7 days |
Reference Values
≤30 mg/dL
Values >30 mg/dL may suggest increased risk of coronary heart disease.
Day(s) and Time(s) Performed
Monday through Saturday; Continuously
Test Classification
This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83695
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LIPA | Lipoprotein (a), S | 10835-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| LIPA | Lipoprotein (a), S | 10835-7 |
Clinical Reference
1. Emerging Risk Factors Collaboration, Erqou S, Kaptoge S, et al: Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. 2009 Jul 22;302(4):412-423
2. Lackner C, Cohen JC, Hobbs HH: Molecular definition of the extreme size polymorphism in apolipoprotein(a). Hum Mol Genet. 1993;2:933-940
3. Albers JJ, Slee A, O'Brien KD, et al: Relationship of apolipoproteins A-1 and B, and lipoprotein(a) to cardiovascular outcomes: the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health Outcomes). J Am Coll Cardiol. 2013 Oct 22;62(17):1575-1579
4. Erqou S, Thompson A, Di Angelantonio E, et al: Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants. J Am Coll Cardiol. 2010 May 11;55(19):2160-2167
Method Description
This test is a particle enhanced immunoturbidimetric assay. Human lipoprotein (a)(Lp[a]) agglutinates with the latex particles coated with anti-Lp(a) antibodies.(Package insert: Roche Lipoprotein (a) Gen.2 reagent. Roche Diagnostic Corp; V2.0 01/2015)
Analytic Time
Same day/1 dayReject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Method Name
Immunoturbidimetric Assay
Forms
If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen.