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Mayo Clinic Laboratories

Test Code MFRU Metanephrines, Fractionated, LCMSMS, Random Urine [14961X]

Specimen Required

5 mL random urine with 6N HCl or Unpreserved random urine

Specimen Minimum Volume

1.5 mL

Specimen Stability

Room temperature: 7 days Refrigerated: 8 days Frozen: 30 days

Method Name

Kinetic Alkaline Picrate • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Includes

Metanephrines, Normetanephrines, Total Metanephrines, Creatinine

Collection Container / Tube

Preferred: Plastic Screw-cap container.
Other Acceptable Container:

Transport / Storage Conditions

Preserved urine: Room temperature
Unpreserved urine: Frozen

Special Instructions

Room temperature stability: 1 week (acidified)
After urine collection, add 6N HCl to maintain a pH below 3.
Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record patients age on test request form and urine vial.

Reference Values

See Laboratory Report

Day(s) Performed

Set up: Mon-Sat; Report available: 2 days

CPT Codes

82570, 83835

Clinical Reference

Useful in the evaluation of pheochromocytoma.

Patient Preparation

It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee, for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference. Medications which are alpha agonists (Aldomet), alpha blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection.

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