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HelpTest Code MHC Oxcarbazepine Metabolite, Serum
Reporting Name
Oxcarbazepine Metabolite (MHC), SUseful For
Monitoring serum concentration during oxcarbazepine therapy
Assessing compliance
Assessing potential toxicity
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Collection Container/Tube: Red top (serum gel/SST is not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen immediately before next scheduled dose.
2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
Oxcarbazepine metabolite: 10-35 mcg/mL
Day(s) and Time(s) Performed
Tuesday through Saturday; 12 a.m.
Saturday; 1 p.m.
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80183
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OMHC | Oxcarbazepine Metabolite (MHC), S | 31019-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81030 | Oxcarbazepine Metabolite (MHC), S | 31019-3 |
Clinical Reference
1. Patsalos P, Berry D, Bourgeois B, et al: Antiepileptic drugs-best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia. 2008 Jul;49(7):1239-1276
2. Johannessen S, Tomson T: Pharmacokinetic variability of newer antiepileptic drugs: when is monitoring needed? Clin Pharmacokinet. 2006;45(11):1061-1075
3. Rifai N, Horwath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018
4. Gonzalez-Esquivel DF, Ortega-Gavilan M, Alcantara-Lopez G, Jung-Cook H: Plasma level monitoring of oxcarbazepine in epileptic patients. Arch Med Res. 2000 Mar-Apr;31(2):202-205
5. Lloyd P, Flesch G, Dieterle W: Clinical pharmacology and pharmacokinetics of oxcarbazepine. Epilepsia. 1994;35(Suppl 3):S10-S13
6. Perucca E: Clinical pharmacology and therapeutic use of the new antiepileptic drugs. Fund Clin Pharmacol. 2001;15:405-417
7. Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnosis. 5th ed. Elsevier; 2012
Method Description
The serum sample is diluted in acetonitrile containing internal standard. The protein precipitate is centrifuged, and a portion of the supernatant is diluted with mobile phase for detection by a tandem mass spectrophotometer (MS/MS).(Unpublished Mayo method)
Analytic Time
Same day/1 dayReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
High-Turbulence Liquid Chromatography Mass Spectrometry (HTLC-MS/MS)
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Neurology Specialty Testing Client Test Request (T732)
-Therapeutics Test Request (T831)