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Test Code PVB19 Parvovirus B19 Antibodies, IgG and IgM, Serum

Additional Codes

Epic: LAB800

Mayo: PARVS

Reporting Name

Parvovirus B19 Ab, IgG and IgM, S

Useful For

Serologic detection of recent or past parvovirus B19 infection

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Advisory Information


This test is intended for patients with at least 7 days of symptoms or asymptomatic individuals with recent exposure to parvovirus B19.

 

For patients with acute, symptomatic presentation, order either  PARVP / Parvovirus B19, Molecular Detection, PCR, Plasma or PARVO / Parvovirus B19, Molecular Detection, PCR, Varies.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

IgG: Negative

IgM: Negative

Day(s) and Time(s) Performed

Monday through Friday; 11 a.m.

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86747 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PARVS Parvovirus B19 Ab, IgG and IgM, S 34950-6

 

Result ID Test Result Name Result LOINC Value
PARVG Parvovirus B19 Ab, IgG, S 29660-8
PARVM Parvovirus B19 Ab, IgM, S 40658-7
PARVN Parvovirus B19 Ab Interpretation 58737-8

Clinical Reference

1. Brown KE, Young NS: Parvovirus B19 in human disease. Ann Rev Med. 1997;48:59-67

2. Markenson GR, Yancey MK: Parvovirus B19 infections in pregnancy. Semin Perinatol. 1998;22(4):309-317

3. Summers J, Jones SE, Anderson MJ: Characterization of the genome of the agent of erythrocyte aplasia permits its classification as a human parvovirus. J Gen Virol. 1983;64;(Pt 11):2527-2532

4. Qui J, Soderlund-Venermo M, Young NS. Human Paravoviruses. Clin Microbiol. Rev. 2017 Jan;30(1):43-113. doi: 10.1128/CMR.00040-16

Method Description

Antibody to parvovirus B19 is detected by a sandwich enzyme immunoassay (EIA) for the detection of IgG or IgM class antibodies in serum or plasma (Biotrin). Specific parvovirus B19 antibodies in specimens bind to antigen-coated microtiter wells. Following a wash step, peroxidase-labeled rabbit-antihuman IgG is added that binds to parvovirus antibody. The antigen-antibody complex is detected by the addition of substrate, which turns blue in the presence of the enzyme peroxidase.(Anderson LJ, Tsou R, Parker RA, et al: Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay. J Clin Microbiol. 1986;24[4]:522-526. Package insert: Parvovirus B19 IgG and IgM Enzyme Immunoassay. DiaSorin, Biotrin; 10/2012)

Analytic Time

Same day/1 day

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Heat-inactivated specimen Reject

Method Name

Enzyme Immunoassay (EIA)

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.

Secondary ID

48395

Profile Information

Test ID Reporting Name Available Separately Always Performed
PARVG Parvovirus B19 Ab, IgG, S No Yes
PARVM Parvovirus B19 Ab, IgM, S No Yes
PARVN Parvovirus B19 Ab Interpretation No Yes