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Mayo Clinic Laboratories

Test Code SMUAB Smooth Muscle Antibody Screen, Serum

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.8 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Gastroenterology and Hepatology Test Request (T728)

Secondary ID

609515

Useful For

Evaluating patients with chronic liver disease in whom the diagnosis of chronic active autoimmune hepatitis is suspected

Reflex Tests

Test ID	Reporting Name	Available Separately	Always Performed
SMAT	Smooth Muscle Ab Titer, S	No	No

Testing Algorithm

If smooth muscle antibody (SMA) screen is positive then the SMA titer will be performed at an additional charge.

Method Name

Indirect Immunofluorescence

Reporting Name

Smooth Muscle Ab Screen, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type	Temperature	Time	Special Container
Serum	Refrigerated (preferred)	21 days
	Frozen	21 days

Reject Due To

Gross hemolysis	Reject
Gross lipemia	Reject
Gross icterus	OK

Reference Values

Negative

Reference values apply to all ages.

Clinical Reference

1. Mieli-Vergani G, Vergani D, Czaja AJ, et al: Autoimmune hepatitis. Nat Rev Dis Primers. 2018 Apr 12;4:18017

2. Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D: Serology in autoimmune hepatitis: A clinical-practice approach. Eur J Intern Med. 2018 Feb;48:35-43

3. Hennes EM, Zeniya M, Czaja AJ, et al: Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008 Jul;48(1):169-176

Method Description

The patient's serum in 1:20 and 1:40 (initial screening) dilutions is added to fresh tissue from mouse stomach/kidney and incubated; fluorescein-conjugated antiglobulin is then added. The slides are read with a fluorescence microscope.(Package insert: Kallestad Mouse Stomach/Kidney. Bio-Rad Laboratories, Inc; 01/2018)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86015

LOINC Code Information

Test ID	Test Order Name	Order LOINC Value
SMAS	Smooth Muscle Ab Screen, S	26971-2

Result ID	Test Result Name	Result LOINC Value
609515	Smooth Muscle Ab Screen, S	26971-2

Day(s) Performed

Monday through Saturday

Report Available

2 to 4 days

Inova Laboratories Additional Information:

Replaces AABG (Actin Antibody IgG)

Inova Laboratories powered by Mayo Clinic Laboratories