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Test Code THE Theophylline

Additional Codes

Epic: LAB35

Specimen Required

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and separate cells after clot formation and within 4 hours of collection. 

Specimen Minimum Volume

0.5 mL

Specimen Stability

Room temperature: 48 hours

Refrigerated: 8 days

Frozen: 3 months

Clinical Significance

Theophylline is used in the treatment of bronchospasm associated with bronchial asthma, chronic bronchitis and pulmonary emphysema. Because of the narrow therapeutic index and the wide inter-individual variability in the rate of theophylline metabolism and clearance, virtually every patient receiving theophylline should have serum concentrations monitored. Measurements obtained with this assay are used in the diagnosis and treatment of theophylline overdose or in monitoring levels of theophylline to help ensure appropriate therapy.

Reference Range

Therapeutic range: 5.0 – 15.0 µg/mL

Rejection Due To

Unlabeled, mislabeled, wrong tube type, QNS

Day(s) and Time(s) Performed


Report Available

Same day

Method Name

Chemiluminescent Micro-particle Immunoassay (CMIA)