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Test Code VALPR Valproic Acid

Important Note

Centrifuge and separate cells after clot formation and within 1 hour of collection. 

Additional Codes

Epic: LAB24

Specimen Required

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gold

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: 

  1. Collect a trough specimen, immediately before next dose.
  2. Centrifuge and separate cells after clot formation and within 1 hour of collection. 

Specimen Minimum Volume

0.5 mL

Specimen Stability

Room temperature: 2 days

Refrigerated: 7 days

Frozen: 3 months

Reference Range

Therapeutic: 50.0 - 100.0 µg/mL

Rejection Due To

Unlabeled, mislabeled, wrong tube type, QNS, grossly hemolyzed.

Report Available

Same day

Clinical Significance

Valproic Acid is a broad-spectrum anticonvulsant drug used solely or in combination with other anticonvulsant drugs for the treatment of absence seizures. It also has demonstrated effectiveness in the management of generalized tonic-clonic and myoclonic seizures, as well as atypical absence, simple and complex partial and mixed grand mal and petit mal seizures. The capability of treating many types of seizures with a single anticonvulsant has resulted in the wide-spread use of valproic acid, particularly in children in whom tonic-clonic and myoclonic seizures are most prevalent. Valproic acid has proven effective in the treatment of many patients otherwise refractory to other anticonvulsant treatments. Most patients receiving valproic acid do not develop a tolerance to its anticonvulsant effects.

Method Name

Chemiluminescent Microparticle Immunoassay (CMIA).




Dipropylacetic Acid

Day(s) Performed