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Test Code VDRLC VDRL, Spinal Fluid

Additional Codes

Epic: LAB207

Mayo: VDSF

Reporting Name

VDRL, CSF

Useful For

Aiding in the diagnosis of neurosyphilis

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

CSF


Specimen Required


Collection Container/Tube: Sterile vial

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Submit specimen collected in vial 2, if possible. If not, note which vial from which the aliquot was obtained.


Specimen Minimum Volume

0.2 mL

Testing Algorithm

If this test is positive, a VDRL titer will be performed at an additional charge.

 

For more information, see Meningitis/Encephalitis Panel Algorithm.

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Frozen (preferred) 14 days
  Refrigerated  14 days

Reference Values

Negative

Reference values apply to all ages.

Day(s) Performed

Tuesday, Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86592

LOINC Code Information

Test ID Test Order Name Order LOINC Value
VDSF VDRL, CSF 5290-2

 

Result ID Test Result Name Result LOINC Value
9028 VDRL, CSF 5290-2

Clinical Reference

1. Miller JN: Value and limitations of nontreponemal and treponemal tests in the laboratory diagnosis of syphilis. Clin Obstet Gynecol. 1975 Mar;18(1):191-203

2. Radolf JD, Tramont EC, Salazar JC: Syphilis (Treponema pallidum). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2865-2892

Method Description

VDRL antigen and spinal fluid are mixed on a 180 RPM rotator. The antigen, a cardiolipin-lecithin coated cholesterol particle, flocculates in the presence of reagin.(US Department of Health, Education and Welfare, National Communicable Diseases Center, Venereal Disease Program: Manual of Tests for Syphilis. Centers for Disease Control; 1969; Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020)

Report Available

1 to 4 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Method Name

Flocculation/Agglutination

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
VDSFQ VDRL Titer, CSF No No