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Test Code VITMA Vitamin A, Serum

Reporting Name

Vitamin A, S

Useful For

Diagnosing vitamin A deficiency and toxicity

 

Monitoring vitamin A therapy

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Patient Preparation: Fasting overnight (12-14 hours) (infants: draw prior to next feeding)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-6 years: 11.3-64.7 mcg/dL

7-12 years: 12.8-81.2 mcg/dL

13-17 years: 14.4-97.7 mcg/dL

≥18 years: 32.5-78.0 mcg/dL

Day(s) and Time(s) Performed

Tuesday, Thursday, Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

84590

LOINC Code Information

Test ID Test Order Name Order LOINC Value
VITA Vitamin A, S 2923-1

 

Result ID Test Result Name Result LOINC Value
7597 Vitamin A 2923-1

Clinical Reference

1. Ball GFM: Vitamins: Their role in the human body. Oxford, Blackwell Publishing, 2004, pp 133-187

2. Ross AC: Vitamin A and carotenoids. In Modern Nutrition in Health and Disease. 10th edition. Edited by ME Shils, M Shike, AC Ross, et al. Philadelphia, Lippincott Williams and Wilkins, 2006, pp 351-375

3. Roberts NB. Taylor A. Sodi R: Chapter 37 Vitamins and Trace Elements. In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Edited by N Rifai, AR Horvath, CT Wittwer. Sixth edition. St. Louis, MO. Elsevier, 2018. pp 639-718

Method Description

Deuterated vitamin A (d[6]-all-trans retinol) is added to serum as an internal standard. Vitamin A (all-trans retinol) and the deuterated internal standard are extracted from the specimens using on-line turbulent flow HPLC and analyzed by liquid chromatography-tandem mass spectrometry using multiple reaction monitoring in positive mode.(Unpublished Mayo method)

Analytic Time

2 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.

Secondary ID

42357