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Test Code ZPP Zinc Protoporphyrin (ZPP)

Important Note

Protect from light

Effective 10/3/2022: Lavender top (EDTA) tube is no longer acceptable.

Additional Codes

Epic: LAB1085

Quest: 948

Specimen Required

Specimen Type: Whole Blood EDTA

Collection Container/Type

Preferred: Royal blue-top (EDTA) plastic trace element blood collection tube

Acceptable: Tan top (EDTA), Royal blue top (sodium heparin), Green top (sodium or lithium heparin), Tan top (sodium heparin)

Specimen Volume: 2 mL

Collection Instructions: 

  • Protect from light (specimen should be foil wrapped to protect from light)

Specimen Minimum Volume

0.5 mL (0.2 mL pediatric)

Specimen Stability

Room temperature: 4 days

Refrigerated: 10 days

Frozen: Unacceptable

Reference Range

Industrial Exposure    <100 mcg/dL

(Refer to current OSHA regulation for exposure criteria.)

Rejection Due To

Hemolysis • Received frozen • Clotted • EDTA (lavender-top) tube • Not protected from light

Day(s) and Time(s) Performed


Report Available

1-2 days

Clinical Significance

Zinc protoporphyrin (ZPP) accumulates in erythrocytes as a result of chronic lead absorption or iron deficiency anemia.

Method Name


This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

CPT Code(s)


Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153


Aluminum and anemia of chronic disease may cause elevated results.


Free Erythrocyte Protoporphyrin,Protoporphyrin, Zinc,ZPP